Follistatin is fascinating protein that can increase muscle mass beyond natural potential by suppressing myostatin. Scientists first identified follistatin while examining porcine (re: pig) follicular fluid in the ovaries.
Follistatin is naturally found in the skeletal muscle of almost all mammals with advanced or developed characteristics, such as humans, rodents, and cows. Follistatin is high in the non-essential amino acid cystine but unlike most proteins discussed in the fitness world, follistatin has carbohydrates attached to it.
Follistatin, specifically Follistatin 344 (FS344), quickly gained popularity in the bodybuilding community as a potential supplement to rapidly increase lean tissue mass. Another protein, follistatin-related gene (FLRG) acts on similar pathways as FS344 regarding its muscle building properties. Increased lean tissue mass could give a bodybuilder an advantage in a competitive setting and be the differentiating factor between first and second place.
Product Name:Follistatin 344
Follistatin 344 Alias:FST
Follistatin 344 Appearance:White to off-white crystalline powder or lumps
Follistatin 344 Grade:Reagent Grade
Follistatin 344 Specification:1mg/vial
How do I use Follistatin 344?
Along with all peptides, always freeze the powder if you are storing it for a while. Once you reconstitute the powder, keep it in a fridge and is safe to use for 7 days. Hence you need to use it immediately.
Dosage for a 10 day cycle:
Day 1: Split bilaterally into the muscle you want to bring up the most: 300mcg.
Day 3: Split bilaterally into the muscle you want to bring up the most: 200mcg.
Day 5: Split bilaterally into the muscle you want to bring up the most: 200mcg.
Day 7: Split bilaterally into the muscle you want to bring up the most: 300mcg.
The muscle building effects can last for up to 3 months afterwards, slowly diminishing.
Follistatin also known as activin-binding protein is a protein that in humans is encoded by the FST gene.Its primary function is the binding and bioneutralization of members of the TGF-β superfamily, with a particular focus on activin, a paracrine hormone.
Follistatin is fascinating protein that can increase muscle mass beyond natural potential by suppressing myostatin.Follistatin, specifically Follistatin 344 (FS344), quickly gained popularity in the bodybuilding community as a potential supplement to rapidly increase lean tissue mass.
Another protein, follistatin-related gene (FLRG) acts on similar pathways as FS344 regarding its muscle building properties. Increased lean tissue mass could give a bodybuilder an advantage in a competitive setting and be the differentiating factor between first and second place.
Follistatin works by binding to and inhibiting transforming growth factor-β (TGF-β) peptides such as myostatin which is responsible for regulating and limiting muscle growth. It's also worth pointing out that myostatin may have a regulatory role in skeletal muscle fibrosis; too much myostatin can impair tissue function and cause chronic disease in vital organs, tissues, and bone marrow.
In additional to suppressing the degenerative properties of myostatin, follistatin also suppresses the pituitary gland synthesis and secretion of follicle-stimulating hormone (FSH). High FSH levels in men may indicate that testicles are not functioning correctly; this condition limits muscle growth, recovery, and normal hormonal function. [6] However, FSH levels that are too low can also negatively impact health and reproductive capabilities.
Whereas some myostatin inhibitors like Trichostatin A (TSA) require daily administration, increased levels of FS344 were observed up to 15 months after initial injection. [7][3] The lack of need for daily administration makes follistatin an attractive alternative for suppressing myostatin.
The recent increase in attention in the science community on follistatin and other myostatin inhibitors is primarily due to the desire to find an alternative means to treat muscle disorders; the most popular current option is androgen steroids which pose a number of side-effects and long-term health risks. At this point you might be wondering why follistatin use isn't more widespread in bodybuilders and other athletes. In the next section we will examine the current research on follistatin and whether it builds muscle mass.
Appearance | White to off white powder | Consistent |
Purity(HPLC) | ≥98% | 99% |
Water | <6.0% | 5.43% |
Acetic Acid | 3.0-8.0% | 6.45% |
Trifluoroacetic Acid | <0.25% | 0.08% |
Peptide | ≥80% | 88.45% |
MS | Consistent | Consistent |
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